Anti-aging General


PRGF-Endoret® anti-aging treatment is recommended as a preventative procedure that slows down the aging process for people over 35 years of age and as a recovery and correction procedure for people over the age of 45. There are no contraindications for the use of this procedure and it can be used by pregnant women. It is compatible with other aesthetic and corrective treatments because no negative interactions with other products used for this purpose have been recorded. Moreover, it is sometimes advisable to combine PRGF-Endoret® with other fillers in order to increase the volume of a given area.

The effects of PRGF-Endoret® treatments are progressive and already visible 24 hours after the first application, while the smoothness and freshness of the skin increases with each new treatment. In the initial phase, three treatments are recommended over three months. The treatment is individually tailored for each patient, and after the initial treatment, one to three treatments per year, depending on the age and type of skin, are required to maintain the existing condition.

The treatment is completely painless and lasts for about an hour. The patient’s blood is drawn at the office which is then centrifuged in order to separate the blood cells from plasma: erythrocytes and, more importantly, leukocytes. By separating leukocytes, the possibility of the occurrence of inflammatory processes is almost impossible. PRGF-Endoret® is the only method of using the patient’s own plasma, in which leukocytes are separated from the plasma and as such, the only EU and FDA-certified methods. Apart from the separation of blood cells, the centrifuge produces two plasma fractions that contain their own hormones and growth factors. After the blood is drawn, the patient is anesthetized by applying anaesthetic cream to the area. After waiting for some time, these plasma fractions are injected into the patient with microneedles.

The results of the anti-aging PRGF-Endoret® treatment are improved skin texture, wrinkle reduction, higher humidity, and fresher and more “radiant” skin appearance, biostimulation of the treated area, creation of new collagen, better blood circulation, and the creation of its own hyaluronic acid. In addition to all of this, it is important to mention that after the treatment there is no change in facial expression nor any inflammatory reaction. The patient is able to continue with their activities a few hours after the procedure.

Tomislav Flegar, DMD, owner of Dental Studio Flegar, is one of the first certified PRGF-Endoret® biotechnology users in implant, dental, and periodontal surgery, as well as in anti-aging treatment.

PRGF-Endoret® anti-aging treatment

  • Permanent skin rejuvenation
  • Slows down the aging process
  • Completely natural treatment with patient’s own blood plasma without injecting foreign bodies
  • The only plasma treatment for skin rejuvenation that has is EU licensed
  • Better blood circulation and creating of the skin’s own hyaluronic acid
  • Reduces loose skin
  • Promotes collagen production
  • Deeply hydrates
  • Reduces wrinkles
  • Fresher and more “radiant” looking skin
  • Initial results are visible after 24 hours
  • No change in facial expression